Multi-Omics Characterization of Lactate-Associated Molecular Subtypes in Lung Cancer Suggests a Role for DKK1 in Lactate-Linked Migration, Invasion, and Lactylation Programs
Consensus clustering identified lactate-associated molecular subtypes and DKK1's role in migration and invasion in lung cancer, suggesting therapeutic implications.
Key Points
The aim is to explore lactate-associated heterogeneity in lung cancer and identify prognostic factors influenced by lactate.
Curated lactate-related genes in lung cancer cohorts.
Applied consensus clustering to define molecular subtypes.
Conducted in vitro assays on candidate genes to assess migration and invasion under lactate exposure.
Developed a LASSO-based gene signature for risk stratification.
Identified two lactate-associated molecular subtypes with distinct immune microenvironment features.
Developed an 11-gene prognostic signature for patient risk stratification.
DKK1 was highlighted as a lactate-responsive gene affecting migration and invasion.