Identification of dysregulated competitive endogenous RNA network driven by copy number variation in colon adenocarcinoma

This is the authors' abstract. We don't add key points for this paper.

Competitive endogenous RNA (ceRNA) network modulation plays a crucial role in pathogenesis of colon adenocarcinoma (COAD). This study analyzed The Cancer Genome Atlas(TCGA) data to identify 151 copy number variation (CNV)-driven lncRNAs in COAD, constructing a ceRNA network (6 lncRNAs-14 miRNAs-68 mRNAs). Functional enrichment revealed their roles in muscle system processes , blood vessel development and extracellular matrix organization. Survival analysis linked LINC00941 amplification to poor prognosis. Two CNV-driven lncRNA-targeting drugs were identified, offering insights into COAD mechanisms and potential biomarkers.