To develop a fast and SNP-tolerant computational framework for accurately aligning short reads and detecting complex genomic variants and splicing events.
Designed and implemented high-performance sequence alignment algorithms within the GMAP software package.
Developed core alignment routines in C with supplementary utility programs in Perl.
Created an open-source tool capable of efficient variant-tolerant and splice-aware short-read mapping.
Provided public access to source code and analysis utilities via the GMAP software distribution.
Abstract
Source code in C and utility programs in Perl are freely available for download as part of the GMAP package at http://share.gene.com/gmap.