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February 27, 2026SHILAP Revista de lepidopterologíaOpen Access

Cross-tissue integrative transcriptomic and multimodal analyses suggest shared immune signatures linking lupus nephritis and cutaneous lupus erythematosus

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Authors

MLMeilu LiHarbin Medical UniversityCSChangze SongSun Yat-sen UniversityZWZilong WangSun Yat-sen University

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Implication

Integrative analyses reveal immune signatures linking lupus nephritis and cutaneous lupus erythematosus, suggesting therapeutic targets.

Key Points

  • The research aims to identify shared molecular signatures linking lupus nephritis and cutaneous lupus erythematosus, potentially guiding future therapies.
  • Analyzed gene expression profiles using bulk transcriptome analysis and single-cell RNA sequencing.
  • Employed weighted gene co-expression network analysis (WGCNA) to identify gene modules associated with clinical traits.
  • Utilized machine learning algorithms (LASSO, SVM-RFE, random forest) to screen for biomarkers.
  • Conducted functional enrichment analyses to characterize implicated pathways.
  • Validated findings in the lupus mouse model C57BL/6-FasLpr.
  • Identified 361 differentially expressed genes (DEGs) in lupus nephritis and 711 DEGs in cutaneous lupus erythematosus.
  • Discovered 99 overlapping genes between LN and CLE.
  • Highlighted immune-related pathways enriched in shared DEGs, particularly type I interferon signaling.
  • Machine learning identified six hub genes with diagnostic AUC values >0.7.
  • In vivo validation showed elevated serum IFN-β levels and altered CD4/CD8 ratios in lupus mice.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69a134b8ed1d949a99abe282https://doi.org/10.3389/fimmu.2026.1716516
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