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February 27, 2026Frontiers in ImmunologyOpen Access

Systematic review and meta−analysis of PET−based prognostic metrics in CAR−T treatment of DLBCL

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Authors

CLChirong LongBengbu Medical CollegeKXKexin XuBengbu Medical CollegeHFHanqi FangBengbu Medical College

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Implication

Systematic review analyzes PET imaging impact on survival outcomes in DLBCL with CAR-T treatment, suggesting important predictive value.

Key Points

  • This research aims to evaluate the relationship between PET imaging parameters and treatment outcomes in DLBCL patients undergoing CAR-T therapy.
  • Conducted a systematic review and meta-analysis of relevant studies.
  • Included cohort studies focusing on DLBCL diagnosed via PET/CT.
  • Utilized fixed-effect and random-effects models to analyze pooled hazard ratios.
  • Assessed heterogeneity using I² statistic.
  • Identified significant associations between PET-derived parameters and survival outcomes.
  • SUVmax predictive of overall survival (OS) and progression-free survival (PFS).
  • Higher metabolic tumor volume (MTV) linked to decreased OS and PFS.
  • Elevated LDH associated with inferior OS and PFS in both univariate and multivariate analyses.

Cite This Study

Long et al. (2026) studied this question.

synapsesocial.com/papers/69a134b8ed1d949a99abe33dhttps://doi.org/10.3389/fimmu.2026.1679181
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