Blastocyst implantation assay: towards the development of a new in vitro model for studying woman-specific blastocyst implantation

In this study we developed an in vitro model to mimic the endometrial exposure to the blastocyst in vitro and to evaluate the maternal tissue response in terms of the amount of trophoblastic spheroids able to adhere to endometrial cultures. Our results underline the high variability existing among healthy patients in their endometrial ability to retain the embryo, pointing out the necessity of developing a test aimed at the customization of in vitro fertilization treatments.