What does this research mean for the field?

Eosinophilic annular erythema may coexist with IgM monoclonal gammopathy of undetermined significance. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe a rare case of eosinophilic annular erythema associated with IgM monoclonal gammopathy and discuss the implications for diagnosis and treatment.

February 27, 2026CureusOpen Access

Eosinophilic Annular Erythema Associated With IgM Monoclonal Gammopathy of Undetermined Significance

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Authors

SIShin Iinuma TKTakahiro KobayashiJapanese Red Cross Hokkaido College of Nursing TNTakahiro NagashimaJapanese Red Cross Hokkaido College of Nursing

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Implication

Case report reveals eosinophilic annular erythema associated with IgM monoclonal gammopathy, highlighting the need for follow-up.

Key Points

To describe a rare case of eosinophilic annular erythema associated with IgM monoclonal gammopathy and discuss the implications for diagnosis and treatment.
Case report of a 73-year-old Japanese woman
Histopathological examination of skin biopsies
Laboratory evaluation for serum IgM and urinary Bence Jones protein
Management with topical corticosteroids and hematological surveillance
The patient presented with pruritic annular plaques and central hyperpigmentation.
Histopathology showed eosinophil-rich dermal infiltrates without vasculitis.
Serum IgM levels were markedly elevated, indicating monoclonal gammopathy.
The skin eruption regressed following treatment with high-potency topical corticosteroids.

Cite This Study

Iinuma et al. (2026) studied this question.

synapsesocial.com/papers/69a134dded1d949a99abe4b6 https://doi.org/10.7759/cureus.104220

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Eosinophilic Annular Erythema Associated With IgM Monoclonal Gammopathy of Undetermined Significance

Discussion

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Implication

Key Points

Cite This Study

Eosinophilic Annular Erythema Associated With IgM Monoclonal Gammopathy of Undetermined Significance

Discussion

Member takes

Implication

Key Points

Cite This Study

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