This study focuses on its effects on uric acid metabolism and hypertension in pregnant mice. Meanwhile, further explore the potential role of uric acid in the occurrence and development of hypertensive disorders complicating pregnancy (HDCP). Pregnant BALB/c mice were selected as the research subjects and randomly divided into two groups. Among them, the model group added mixed antibiotics to their daily drinking water. Using 16S rRNA gene sequencing technology to accurately evaluate the specific changes in the gut microbiota of mice after antibiotic administration. Subsequently, the study focused on the effects of changes in gut microbiota on uric acid metabolism and the degree of hypertension in pregnant mice. To further verify the role of uric acid in it, the effect of adding uric acid intervention to mouse feed on hypertension in pregnant mice was observed, providing strong evidence for a comprehensive understanding of the physiological and pathological mechanisms related to pregnancy. Microbial analysis revealed that administration of mixed antibiotics markedly shifted the gut microbiota structure, dramatically reduced both α diversity and β diversity, as well as a decrease in the abundance of probiotics such as Bifidobacterium and Akkermansia. Gut microbiota dysbiosis led to elevated uric acid levels and heightened intestinal inflammation. After incorporating uric acid crystals into the diet of mice, levels of ACE increased and endothelin-1 and ACE2 levels decreased. Additionally, the HDCP marker sFlt1/PlGF was elevated. Decreased gut microbiota abundance and probiotic depletion promoted uric acid production and the degree of hypertension, and the elevated uric acid produced may promote the onset and development of HDCP. This study should improve our understanding of how gut microbiota influence distant physiological processes and HDCP states through their metabolic products.
Chang et al. (Wed,) studied this question.