Demonstrates a nickel-catalyzed deprotection process in peptide synthesis, suggesting a sustainable alternative to palladium methods.
We report a one-step, nickel-catalyzed allyl/alloc deprotection compatible with solid-phase peptide synthesis (SPPS) to address the reliance on costly palladium conditions and limited on-resin compatibility of base-metal alternatives. Our two-component system employs an air-stable Ni(PPh₃)₂Br₂ precatalyst and NH₃BH₃ reductant and operates rapidly in SPPS-compatible solvents under inertion. This protocol efficiently and chemoselectively deprotects allyl- and alloc-protected amino acids, small molecules, and peptides in solution and has been extended to on-resin deprotection, showing promise for SPPS applications.
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Aguilera et al. (2026) studied this question.
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