Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [¹⁸F]PI-2620 PET.

Key Points

This research aims to track tau aggregation patterns in progressive supranuclear palsy using PET imaging.
Utilized [18F]PI-2620 PET imaging for longitudinal monitoring.
Focused on individuals diagnosed with progressive supranuclear palsy.
Analyzed tau progression over different disease stages.
Detected tau aggregation using PET imaging.
Observed network-based propagation of tau throughout the progressive supranuclear palsy stages.
Noted saturation of tau in advanced stages.

Longitudinal analysis of tau progression in progressive supranuclear palsy demonstrates network-based propagation, suggesting disease evolution.

[¹⁸F]PI-2620 PET enables monitoring of tau progression in PSP, indicating network-based tau propagation with saturation in advanced stages.

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Gnörich et al. (2026) studied this question.

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