Novel method shows efficient access to exocyclic olefinic azacycles in N-heterocyclic carboxylic acids, suggesting a new approach in organic synthesis.
A radical-mediated methylenation of N-heterocyclic carboxylic acids with DMSO is developed using KF as a catalyst, which allows efficient access to exocyclic olefinic azacycles. This novel strategy features transition metal-free conditions, the direct use of DMSO as a methylene source, and a free-radical cascade process.
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He et al. (2026) studied this question.
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