This research explores mechanisms of intestinal injury from radiation via mitochondrial dysfunction, suggesting new treatment strategies.
Mitochondrial dysfunction driven by the dysregulation of genes related to mitochondrial function (nuclear genes and mitochondrial genome) is a key mechanism of RIII pathogenesis. At present, research on pivotal regulators remains limited, necessitating deeper investigation with multi-omics approaches. Precisely targeting these mitochondrial function-related genes offers a promising therapeutic strategy for reducing mitochondrial damage and treating RIII.
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Zhang et al. (2026) studied this question.
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