Identifies Mrm2's role in worsening mitochondrial dysfunction in radiation-induced intestinal injury, suggesting a potential therapeutic target.
Radiation-induced intestinal injury (RIII) is a serious complication of radiotherapy and is closely related to mitochondrial dysfunction, yet its mechanism remains unclear. In this study, a series of mitochondrial-related differentially expressed genes were identified in the RIII model, whose core functional modules include mitochondrial-coding genes and apoptosis-related genes. Histopathological staining analysis indicated that RIII shows a significant dose- and time-dependent aggravation. Experiments showed Mrm2 was continuously upregulated after irradiation in vivo. Mrm2 may serve as a key regulatory factor for mitochondrial dysfunction in RIII.
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Zhang et al. (2026) studied this question.
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