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February 27, 2026Open Access

Prognostic significance of neutrophil-to lymphocyte ratio and platelet-to lymphocyte ratio in older patients with metastatic colorectal cancer.

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Authors

MCMarlid Cruz-RamosLNLaura del Puerto NevadoBZbinbin Binbin Zheng

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Overview

This retrospective study assesses neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios' prognostic value in older metastatic colorectal cancer patients, suggesting they can be effective...

Key Points

  • This research aims to determine the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in older patients with metastatic colorectal cancer (mCRC).
  • Retrospective review of 110 patients with a mean age of 72.2 years at diagnosis.
  • NLR and PLR calculated and categorized using ROC curve cutoffs.
  • Survival curves and Cox regression analysis performed for progression-free survival (PFS) and overall survival (OS).
  • High NLR correlated with worse PFS (10 vs 16 months) and OS (20 vs 26 months).
  • High NLR had a hazard ratio (HR) of 2.00 for PFS and 2.28 for OS.
  • High PLR also linked to poorer survival outcomes, with PFS at 9 vs 15 months and OS at 19 vs 25 months.
  • High PLR showed HR of 1.55 for PFS and 2.35 for OS.

Cite This Study

Cruz-Ramos et al. (2019) studied this question.

synapsesocial.com/papers/69a13550ed1d949a99abf0f2https://doi.org/10.5281/zenodo.18775255
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluating the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic and treatment response biomarkers in stage IV colorectal cancer patients2024 · 1 citations
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  3. 3The prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in colorectal cancer patients experiencing anastomotic leakage：a retrospective study2024
  4. 4The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer2013 · 70 citations
  5. 5Evaluating Preoperative Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios as Predictors of Lymph Node Metastasis in Gastric Cancer2024