What question did this study set out to answer?

To explore ADHD heterogeneity and biotypes using topological deviations in morphometric similarity networks.

February 27, 2026JAMA Psychiatry

Mapping ADHD Heterogeneity and Biotypes by Topological Deviations in Morphometric Similarity Networks

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This case-control study identifies distinct ADHD biotypes with unique profiles, suggesting personalized management approaches.

To explore ADHD heterogeneity and biotypes using topological deviations in morphometric similarity networks.
Case-control study design
Integration of normative modeling with semisupervised clustering
Analysis of morphometric similarity networks
Identification of 3 distinct ADHD biotypes
Each biotype has unique clinical-neural profiles
Insights into ADHD's neurobiological complexity were revealed

Pan et al. (2026) studied this question.

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