PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 27, 20260 citations

Novel Variants in the IL-38 Gene Shape Genetic Susceptibility in Systemic Lupus Erythematosus.

View Full Paper
QSQingxue ShuAHAnfang HuangCHChengsong He

Key Points

  • Investigate the relationship between IL-38 gene polymorphisms and susceptibility to systemic lupus erythematosus (SLE).
  • Analyzed IL-38 gene polymorphisms (rs3811058 and rs7599662)
  • Established association with SLE susceptibility
  • Examined correlation with clinical and laboratory features
  • Identified significant association between IL-38 gene polymorphisms and SLE
  • Noted partial correlations with specific clinical features
  • Findings suggest broader implications for genetic susceptibility

Abstract

IL-38 gene polymorphisms (rs3811058 and rs7599662) are associated with SLE susceptibility, and are partially associated with clinical and laboratory features.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Shu et al. (2026) studied this question.

synapsesocial.com/papers/69a13591ed1d949a99abf906https://doi.org/10.1111/1756-185x.70581
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Low heterozygosity for rs3811050, a 5 prime untranslated region variant of the gene encoding interleukin-38 (IL1F10), is associated with a reduced risk of systemic lupus erythematosus2024 · 4 citations
  2. 2Exon 2 variants (rs3811046 and rs3811047) of the IL37 gene are associated with susceptibility to systemic lupus erythematosus2024 · 5 citations
  3. 3Association of interleukin-38 and its polymorphism (rs7599662) with ulcerative colitis2026
  4. 4Interleukin 18 (-137G/C, -607C/A) Polymorphisms as Genetic Biomarkers of Susceptibility to Systematic Lupus Erythematosus2024 · 2 citations
  5. 5Identification of a new putative functional IL18 gene variant through an association study in systemic lupus erythematosus2009 · 50 citations