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Synapse
February 27, 20261 citations

Strategic targeting of mitochondria in ischemic heart disease: mechanisms and emerging therapies.

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GKGino A KurianEGEren Rose GinoMarquette University

Key Points

  • This research aims to explore targeted therapies for mitochondrial injury in ischemic heart disease (IHD).
  • Analyzed mechanisms of mitochondrial injury and adaptive failure in IHD.
  • Reviewed strategies for biomarker-guided patient stratification.
  • Evaluated optimized systems for drug delivery.
  • Discussed design considerations for clinical trials.
  • Identified key therapeutic window stages for effective intervention.
  • Highlighted the necessity of biomarker-guided treatment strategies.
  • Showed potential for improved clinical outcomes through optimized delivery systems.

Abstract

Precision targeting of mitochondrial injury and adaptive failure offers stage-specific therapeutic opportunities in IHD; however, successful translation requires biomarker-guided stratification, optimized delivery systems, and temporally aligned clinical trial design.

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Cite This Study

Kurian et al. (2026) studied this question.

synapsesocial.com/papers/69a13591ed1d949a99abf92fhttps://doi.org/10.1080/14779072.2026.2637751
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decoding interaction between mitochondria and endoplasmic reticulum in ischemic myocardial injury: targeting natural medicines2025 · 4 citations
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  4. 4Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment2021 · 54 citations
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