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This review aims to examine the predictive value of polygenic risk scores for depression within gene-environment interaction studies.

February 27, 2026Translational PsychiatryOpen Access

The predictive value of polygenic risk scores for depression in gene-environment interaction studies: a systematic review

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This review aims to examine the predictive value of polygenic risk scores for depression within gene-environment interaction studies.
Conducted a systematic literature search based on PRISMA guidelines.
Analyzed 56 studies focusing on gene-environment interactions in depression.
Included various adverse and protective environmental exposures across the lifespan.
Most studies reported significant effects of polygenic risk scores and environmental exposures on depression.
Evidence for gene-environment interactions was heterogeneous and mostly from large cohort studies.
PRS and environmental interactions explained a small variance in depression, requiring large sample sizes for detection.

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Systematic review shows polygenic risk scores impact depression outcomes, indicating gene-environment correlations.

Illius et al. (2026) studied this question.

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