New Aspects of Application of Methyl-4-Thieno[3,2-]Pyrrole-5-Carboxylates and Derivatives in Synthesis. A Review

This review summarizes the results of the authors' study of chemical transformations of basic N-substituted methyl -thieno[3,2-]pyrrolecarboxylate in two main directions concerning the synthesis of new polymers and heterocycles (isoquinolines). In the first part presents data on the synthesis of a series of polyheterofunctionalized polymers based on the first developed from monomeric starting 4N-substituted bis-4-thieno[3,2-]-pyrrolomethanes and structurally similar products of cross-coupling (1-pyrrol-3-ylmethyl)-4-thieno[3,2-]-pyrroles, their physicochemical properties were studied, possible step-by-step routes of formation and examples of practical use were proposed. In the second part the results obtained in the course of studying the AlCl-promoted acylation reactions of -benzyl- and -2,3-dimethoxybenzyl-substituted methyl 4-thieno[3,2-]-pyrrole carboxylates with acid chlorides of the above-mentioned acids with the isolation of a new topology isoquinolines fused with 4H-thieno[3,2-]pyrrole and benzene rings are discussed.