This novel open surgical model reliably induces mixed mucosal and structural airway stenosis, offering precise control over the injury site. Additionally, this study provides the first quantitative evidence of therapeutic potential for nebulized ciprofloxacin/dexamethasone, demonstrating attenuated mucosal inflammation and airway narrowing, and presents a reproducible model for the preclinical evaluation of airway stenosis treatments.
Swami et al. (Tue,) studied this question.