Chronic PFOA and PFOS Exposure Triggers Cellular Oxidative Stress and Alters Lipid Levels as Revealed through Multi-omics Analysis

Key Points

• This research aims to investigate the long-term cellular effects of PFOA and PFOS exposure, particularly focusing on oxidative stress and lipid levels.
• Conducted a 24-week chronic exposure model
• Evaluated cellular responses using multi-omics analysis
• Measured oxidative stress markers and lipid profiles
• Chronic exposure significantly increased oxidative stress levels
• Altered lipid profiles were observed, indicating metabolic disruption
• Findings suggest potential links to various health disorders associated with PFAS exposure

Abstract