Why the study?
Does increasing pyruvate dehydrogenase (PDH) flux with dichloroacetate improve cardiac function and restore substrate use in a rodent model of type 2 diabetes?
Population
Rodent model of type 2 diabetes
Comparison
Dichloroacetate for 28 days vs Untreated diabetic animals and non-diabetic…
Design
Preclinical
Follow-up
28 days
Authors
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Does not support clinical use; hypothesis-generating for PDH activation in diabetic cardiomyopathy.
Does increasing pyruvate dehydrogenase (PDH) flux with dichloroacetate improve cardiac function and restore substrate use in a rodent model of type 2 diabetes?
In a rodent model of type 2 diabetes, increasing pyruvate dehydrogenase flux with dichloroacetate restored myocardial substrate selection, reversed diastolic dysfunction, and normalized blood glucose levels, suggesting a potential novel therapy for diabetic cardiomyopathy.
Page et al. (2015) studied this question.
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