February 1, 2006DiabetesOpen Access

Increased Myocardial Oxygen Consumption Reduces Cardiac Efficiency in Diabetic Mice

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Why the study?

Does diabetes reduce cardiac efficiency in mouse models of type 1 and type 2 diabetes?

Population

Ex vivo working hearts from control db/+, db/db, and db/+ mice given streptozotocin

Comparison

Type 1 and Type 2 diabetes models evaluated at… vs Control db/+ mice

Design

Preclinical

Authors

OHOle-Jakob HowNord University EAEllen AasumCentre for Arctic Gas Hydrate, Environment and Climate DSDavid L. SeversonHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

Should not change clinical practice; leaves open translation of reduced cardiac efficiency to human diabetic cardiomyopathy.

Structured PICO

Does diabetes reduce cardiac efficiency in mouse models of type 1 and type 2 diabetes?

Population

Ex vivo working hearts from control db/+, db/db (type 2 diabetes), and db/+ mice given streptozotocin (type 1 diabetes)

Intervention

Type 1 and Type 2 diabetes models evaluated at low (0.3 mmol/l) and high (1.4 mmol/l) fatty acid concentrations

Comparator

Control db/+ mice

Outcome

Cardiac efficiency (ratio of cardiac work [PVA] and myocardial oxygen consumption [MVo(2)])surrogate

Diabetic hearts exhibit decreased cardiac efficiency driven by increased oxygen consumption for noncontractile purposes.

Cite This Study

How et al. (2006) studied this question.

synapsesocial.com/papers/69a1748e0ea4b810780ae6e2 https://doi.org/10.2337/diabetes.55.02.06.db05-1164

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Increased Myocardial Oxygen Consumption Reduces Cardiac Efficiency in Diabetic Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increased Myocardial Oxygen Consumption Reduces Cardiac Efficiency in Diabetic Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider