Why the study?
Does tight blood pressure control with captopril prevent macrovascular and microvascular complications compared to atenolol in hypertensive patients with type 2 diabetes?
Population
Hypertensive patients with type 2 diabetes (mean age 56 years, mean blood pressure 160/94 mm Hg)
Comparison
Tight blood pressure control with captopril vs Tight blood pressure control with atenolol
Design
RCT, Randomised
Follow-up
9 years
Authors
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BP lowering with either agent equally reduces complications in hypertensive type 2 diabetes; confirms target BP, not drug class, drives benefit.
Does tight blood pressure control with captopril prevent macrovascular and microvascular complications compared to atenolol in hypertensive patients with type 2 diabetes?
Blood pressure reduction itself appears to be more important than the specific choice between an ACE inhibitor (captopril) or a beta-blocker (atenolol) for preventing complications in hypertensive patients with type 2 diabetes.
UK Prospective Diabetes Study Group (1998) studied this question.
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