What does this research mean for the field?

Women with type A acute aortic dissection experience longer diagnosis times, lower rates of surgical repair, and higher in-hospital mortality compared to men. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

Assess sex-related differences in clinical characteristics, management, and outcomes for type A and B acute aortic dissection.

February 28, 2026Journal of the American Heart AssociationOpen Access

Sex‐Related Differences in Clinical Profile, Management, and Outcomes of Patients With Type A and B Acute Aortic Dissection: Observations From IRAD

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Assess sex-related differences in clinical characteristics, management, and outcomes for type A and B acute aortic dissection.
Analyzed data from 11,586 patients enrolled in the IRAD from 1996 to 2022.
Compared demographic and clinical characteristics between men and women.
Evaluated treatment approaches and in-hospital and long-term survival rates.
One-third of patients were women, with older women presenting with both types of AAD.
Women experienced longer diagnosis times and had more common symptoms like hypotension and altered mental status in TA-AAD.
Surgical repair for TA-AAD was less frequent in women, while medical management was more common among women than men.
Women had higher in-hospital mortality rates for TA-AAD, with lower 4-year survival compared to men.

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Implication

Observes sex-related differences in clinical characteristics and outcomes in acute aortic dissection patients, suggesting targeted management approaches are needed.

Cite This Study

Jackson et al. (2026) studied this question.

synapsesocial.com/papers/69a285aa0a974eb0d3c009aa https://doi.org/10.1161/jaha.124.037506

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Implication

Observes sex-related differences in clinical characteristics and outcomes in acute aortic dissection patients, suggesting targeted management approaches are needed.

Sex‐Related Differences in Clinical Profile, Management, and Outcomes of Patients With Type A and B Acute Aortic Dissection: Observations From IRAD

Key Points

Discussion

Implication

Cite This Study

Sex‐Related Differences in Clinical Profile, Management, and Outcomes of Patients With Type A and B Acute Aortic Dissection: Observations From IRAD

Key Points

Discussion

Implication

Cite This Study

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