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February 28, 2026SHILAP Revista de lepidopterologíaOpen Access

Polychlorinated biphenyls and breast cancer: evidence, mechanisms, and risk management

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Authors

SZShuaiyang ZhangHCHongliang CaoRLRunzhou Lian

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Overview

This review uncovers mechanisms linking polychlorinated biphenyls to breast cancer, suggesting a framework for managing risks.

Key Points

  • This review aims to clarify the relationship between polychlorinated biphenyls (PCBs) and breast cancer by identifying mechanisms of action and proposing risk management strategies.
  • Synthesis of multi-disciplinary evidence on the role of PCBs in breast cancer.
  • Analysis of how PCBs interact with cellular pathways, including metabolic and epigenetic processes.
  • Examination of receptor interactions, particularly the aryl hydrocarbon receptor and estrogen receptor.
  • PCBs are characterized as active drivers of tumorigenesis rather than mere exposure correlates.
  • Mechanisms include mitochondrial dysfunction and inhibition of TET enzymes leading to epigenetic changes.
  • A framework for integrating environmental remediation and clinical interventions is proposed, linking PCB exposure to breast cancer risk.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69a285aa0a974eb0d3c00a08https://doi.org/10.3389/fcell.2026.1744112
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Also Consider

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