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February 28, 2026Frontiers in ImmunologyOpen Access

Alleviation of experimental arthritis in SKG mice through Nr4a1 agonization

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Authors

YNY. NakayamaRHRyosuke HiwaAOAyaka Okubo

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Overview

Experimental intervention with CsnB shows therapeutic effects on arthritis in SKG mice, suggesting a novel immunotherapeutic approach.

Key Points

  • This study investigates the effect of CsnB, an Nr4a1 agonist, on T cell-mediated arthritis in SKG mice.
  • Induction of arthritis in SKG mice using zymosan A
  • Intraperitoneal treatment with CsnB
  • Evaluation of disease severity via clinical scoring
  • Flow cytometry analysis of immune cell populations
  • In vitro assays of T cell activation and differentiation
  • CsnB significantly reduced arthritis severity in SKG mice
  • Decreased populations of effector memory and Th17 cells in spleen and synovium
  • Suppressed T cell activation and downregulated IL-2 and activation markers in vitro
  • Inhibited Th17 differentiation and modified IL-6 signaling pathway

Cite This Study

Nakayama et al. (2026) studied this question.

synapsesocial.com/papers/69a285aa0a974eb0d3c00ac3https://doi.org/10.3389/fimmu.2026.1758616
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