Disappearing Thyroid Nodules: A Case Report and Review of Evidence

We present the case of a 24-year-old African-American woman who noticed an anterior cervical mass during self-examination 2 weeks prior. Although she experienced no compressive, local or systemic symptoms, she expressed aesthetic concerns. Ultrasound findings identified a single left thyroid nodule, cystic and with internal septations and eccentric solid areas (EU-TIRADS 2) measuring 22.9 mm in maximum diameter, warranting fine-needle aspiration (FNA) due to aesthetic concerns. Initial blood tests showed no inflammatory markers or thyroid axis abnormalities. Despite recommendations for therapeutic intervention, the patient declined the procedure after observing a reduction in the mass. Four months later, follow-up ultrasound revealed complete resorption of the nodule. This report reviews evidence on thyroid nodule disappearance/resorption, emphasizing the importance of individualized, patient-centered care.