Preliminary Safety Outcomes of Single Versus Dual Antiplatelet Therapy Combined with the Pipeline Flex Embolization Device with Shield Technology for Intracranial Aneurysm Treatment: A Retrospective Single-Center Analysis

Q: What does this research mean for the field?

Single antiplatelet therapy with clopidogrel is as safe as dual antiplatelet therapy for patients treated with the Pipeline Flex Embolization Device with Shield Technology for intracranial aneurysms. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ti-Yung Tseng; Shin-Nan Lin; Ching-Chang Chen; Yi-Ming Wu; Chun-Ting Chen; Yao-Liang Chen; Chih-Hua Yeh; Mun-Chun Yeap; Ho-Fai Wong

doi:10.3174/ajnr.a9268

February 25, 2026American Journal of NeuroradiologyOpen Access

Preliminary Safety Outcomes of Single Versus Dual Antiplatelet Therapy Combined with the Pipeline Flex Embolization Device with Shield Technology for Intracranial Aneurysm Treatment: A Retrospective Single-Center Analysis

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Key Points

To compare the safety profiles of single versus dual antiplatelet therapy for patients treated with the Pipeline Flex Embolization Device.
Retrospective single-center comparative study
Patients treated with either single or dual antiplatelet therapy
Primary endpoint: major ischemic stroke within 1 year
Secondary endpoints: minor ischemic events, major hemorrhagic events, aneurysm occlusion rates
Kaplan–Meier method used for primary endpoint analysis
172 patients included: 91 in the single therapy group and 81 in the dual therapy group
1-year risk of major ischemic stroke: 2.2% for single therapy vs. 1.3% for dual therapy (P = .62)
Rates of minor ischemic events, major hemorrhage, and occlusion were comparable between groups
Single therapy group had more high-risk aneurysms than dual therapy (16.0% vs. 4.4%; P = .004)

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Implication

This retrospective analysis compares safety between single and dual antiplatelet therapies for intracranial aneurysms, suggesting potential for simpler treatment options.

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Tseng et al. (2026) studied this question.

synapsesocial.com/papers/69a286240a974eb0d3c00dd2 https://doi.org/10.3174/ajnr.a9268

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Preliminary Safety Outcomes of Single Versus Dual Antiplatelet Therapy Combined with the Pipeline Flex Embolization Device with Shield Technology for Intracranial Aneurysm Treatment: A Retrospective Single-Center Analysis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Preliminary Safety Outcomes of Single Versus Dual Antiplatelet Therapy Combined with the Pipeline Flex Embolization Device with Shield Technology for Intracranial Aneurysm Treatment: A Retrospective Single-Center Analysis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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