What does this research mean for the field?

Eosinophilic granulomatosis with polyangiitis (EGPA) can emerge during benralizumab therapy, but can be successfully managed by switching to mepolizumab therapy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

This report aims to highlight the emergence of eosinophilic granulomatosis with polyangiitis during benralizumab therapy and its successful management via mepolizumab.

February 28, 2026Journal of Asthma and AllergyOpen Access

A Case of Eosinophilic Granulomatosis with Polyangiitis Emerging During Benralizumab Therapy: Successful Management Through a Switch to Mepolizumab Therapy

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Authors

YSYuki SaitoJuntendo University JIJun ItoJuntendo University TWTakayasu WatanabeJuntendo University

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Implication

A case demonstrates the successful management of eosinophilic granulomatosis with polyangiitis through a treatment switch in a patient with asthma.

Key Points

This report aims to highlight the emergence of eosinophilic granulomatosis with polyangiitis during benralizumab therapy and its successful management via mepolizumab.
Case study of a 70-year-old man with a history of asthma and eosinophilic pneumonia.
Monitoring of clinical symptoms and laboratory markers including eosinophil count, RF, MPO–ANCA, and IgE levels.
Transitioning from benralizumab to mepolizumab for treatment.
Initial treatment with benralizumab led to temporary improvement but later exacerbation and additional symptoms.
Confirmation of EGPA diagnosis through skin biopsy revealing granulomatous inflammation.
Switching to mepolizumab treatment resulted in clinical resolution of symptoms.

Cite This Study

Saito et al. (2026) studied this question.

synapsesocial.com/papers/69a286240a974eb0d3c00dd4 https://doi.org/10.2147/jaa.s568930

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Implication

A case demonstrates the successful management of eosinophilic granulomatosis with polyangiitis through a treatment switch in a patient with asthma.

A Case of Eosinophilic Granulomatosis with Polyangiitis Emerging During Benralizumab Therapy: Successful Management Through a Switch to Mepolizumab Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

A Case of Eosinophilic Granulomatosis with Polyangiitis Emerging During Benralizumab Therapy: Successful Management Through a Switch to Mepolizumab Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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