Evaluation finds inflammation indices provide limited predicting capabilities for malignancy in thyroid nodules, suggesting a need for better diagnostic tools.
The SII demonstrated independent but clinically limited diagnostic value in differentiating malignant from benign thyroid lesions. Although its accuracy was poor (AUC <0.6), the SII may serve as a low-cost adjunct within multivariable preoperative models, particularly in indeterminate cytology cases.
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Çatak et al. (2026) studied this question.
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