Three-Component Cyclization of Phenyl-1,3-dicarbonyls with α,β-Enaldehydes and 2-(Aminomethyl)aniline into Pyrido[2,1-]quinazolines

Three-component reaction of phenyl-1,3-dicarbonyl compounds with α,β-unsaturated aldehydes and 2-(aminomethyl)aniline under mild conditions leads to regio- and chemoselective formation of - and -diastereomers of tetrahydro-7-pyrido[2,1-]quinazolines. In most cases these products were isolated individually. The spatial structure of the heterocycles was proved based on H, C, 2D H-C HSQC/HMBC, H-H NOESY NMR spectroscopy and X-ray diffraction data.