What question did this study set out to answer?

The aim is to explore advanced drug delivery systems for enhancing the efficacy of 5-fluorouracil.

Recent Advances and Future Directions in 5-Fluorouracil Drug Delivery: A Comprehensive Review

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This comprehensive review examines innovative strategies to improve 5-fluorouracil delivery, suggesting new directions for optimized outcomes.

The aim is to explore advanced drug delivery systems for enhancing the efficacy of 5-fluorouracil.
Systematic examination of innovative delivery strategies
Utilization of molecular engineering approaches
Analysis of microenvironmental regulation strategies
Development of multifunctional, stimuli-responsive carriers
Exploration of multidimensional synergistic approaches
New strategies enhance permeability, solubility, and targeted release of 5-FU
Microenvironment modulation improves therapeutic efficacy and counters drug resistance
Synergistic delivery methods significantly increase 5-FU bioavailability
Innovative approaches reduce systemic toxicity and optimize clinical outcomes

Shu et al. (2026) studied this question.

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This comprehensive review examines innovative strategies to improve 5-fluorouracil delivery, suggesting new directions for optimized outcomes.