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The study investigates the protective effects of IAA-based hydrazone derivatives against cadmium-induced toxicity, focusing on Nrf2-mediated antioxidant activation.

February 28, 2026MetabolitesOpen Access

Untargeted LC–MS/MS Metabolomics Reveals Nrf2-Mediated Antioxidant Activation and Metabolic Reprogramming by IAA-Based Hydrazone Derivatives in Subchronic Cadmium Toxicity

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The study investigates the protective effects of IAA-based hydrazone derivatives against cadmium-induced toxicity, focusing on Nrf2-mediated antioxidant activation.
Rat model randomized into control, Cd-exposed, and treatment groups with MBIH, FBIH, or ascorbic acid.
Treatment lasted 28 days, assessing body weight, blood glucose, HbA1c, and serum biomarkers.
Antioxidant capacity evaluated via GSH assays; qRT-PCR analyzed expression levels of SOD2, CAT, Nrf2, and Hmox 1.
Untargeted LC–MS/MS metabolomic profiling and histopathological examination of various organs were performed.
Cd exposure caused significant weight loss, hyperglycemia, dyslipidemia, and elevated inflammatory markers.
Oxidative stress confirmed by GSH depletion and downregulation of antioxidant genes.
Metabolomics identified specific changes in sulfur amino acid and phospholipid metabolism due to Cd.
MBIH and FBIH treatment restored glycemic control, lipid profiles, and upregulated antioxidant genes through Nrf2 activation.

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Implication

Evaluation of IAA-based hydrazone derivatives mitigating cadmium toxicity in rats, suggesting their protective potential against heavy metal damage.

Cite This Study

Munir et al. (2026) studied this question.

synapsesocial.com/papers/69a287130a974eb0d3c0288d https://doi.org/10.3390/metabo16030155

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Implication

Evaluation of IAA-based hydrazone derivatives mitigating cadmium toxicity in rats, suggesting their protective potential against heavy metal damage.

Untargeted LC–MS/MS Metabolomics Reveals Nrf2-Mediated Antioxidant Activation and Metabolic Reprogramming by IAA-Based Hydrazone Derivatives in Subchronic Cadmium Toxicity

Key Points

Discussion

Implication

Cite This Study

Untargeted LC–MS/MS Metabolomics Reveals Nrf2-Mediated Antioxidant Activation and Metabolic Reprogramming by IAA-Based Hydrazone Derivatives in Subchronic Cadmium Toxicity

Key Points

Discussion

Implication

Cite This Study

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