Symptom burden in young adult brain tumor survivors: key intervention targets based on patient-reported outcome network analyses

Lay Summary Young adult survivors of cancer may experience long-term physical, emotional, and social difficulties, particularly after a brain tumor. In this study, we examined how these sequelae relate to one another, rather than considering each outcome separately. Survivors of brain tumors reported a higher overall burden and showed weaker connections between different domains of daily functioning. However, fatigue, physical functioning, work, and sexual difficulties appeared to link multiple aspects of wellbeing. These findings suggest that certain problems may play a central role in shaping long-term quality of life and could be important targets for personalized follow-up care and rehabilitation.