A New Method for Constructing Aryl-Substituted 3,3,4-Trihydroxy-2,3,4-Tetrahydrobenzimidazo2,1-b1,3Thiazin-5-ium Salts

Key Points

• To develop a novel method for synthesizing aryl-substituted 3,3,4-trihydroxy-2,3,4-tetrahydrobenzimidazo thiazinium salts.
• Utilized acetal-containing chloroxyranes and chloroketones as reactants.
• Reacted with ethyl-2-mercaptobenzimidazole in a 95% ethanol solution.
• Applied microwave irradiation for the reaction process.
• Achieved high yields of up to 93% for the thiazinium salts.
• Synthesized previously undescribed thiazinium compounds of interest to medicinal chemistry.