New method synthesizes high-yield thiazinium salts in medicinal chemistry, implying potential drug development applications.
By the reaction of acetal- containing chloroxyranes and - chloroketones with -ethyl-2-mercaptobenzimidazole in a 95% ethanol solution using microwave irradiation, a new preparative method for the synthesis of previously undescribed 3,3,4-trihydroxybenzimidazo[2,1-][1,3]thiazinium salts with high yields up to 93%, of interest to medicinal chemistry, has been developed.
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F. I. Guseinov (2025) studied this question.
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