What question did this study set out to answer?

The aim is to report the case of a high-risk patient with IgG-negative immunotactoid glomerulopathy and the efficacy of sequential treatment with corticosteroids and cyclosporine A.

February 28, 2026CureusOpen Access

Sequential Treatment With Corticosteroids and Cyclosporine A in a High-Risk Patient With IgG-Negative Immunotactoid Glomerulopathy

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The aim is to report the case of a high-risk patient with IgG-negative immunotactoid glomerulopathy and the efficacy of sequential treatment with corticosteroids and cyclosporine A.
Case report of an 82-year-old woman with nephrotic syndrome and progressive renal dysfunction.
Diagnosis confirmed via electron microscopy despite negative IgG staining.
Treatment administered sequentially with corticosteroids and cyclosporine A, monitoring clinical response.
Patient experienced near-complete remission with proteinuria reducing from 13.8 g/g to 0.24 g/g creatinine.
eGFR improved from 16.0 mL/min/1.73 m² to stabilized at 25.4 mL/min/1.73 m² after treatment.
No underlying hematologic malignancy was found, indicating a distinct case of ITG.

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Implication

A case demonstrates successful treatment of IgG-negative immunotactoid glomerulopathy in a high-risk patient, suggesting a new management approach.

Cite This Study

Inoue et al. (2026) studied this question.

synapsesocial.com/papers/69a287350a974eb0d3c02b83 https://doi.org/10.7759/cureus.104280

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Implication

A case demonstrates successful treatment of IgG-negative immunotactoid glomerulopathy in a high-risk patient, suggesting a new management approach.

Sequential Treatment With Corticosteroids and Cyclosporine A in a High-Risk Patient With IgG-Negative Immunotactoid Glomerulopathy

Key Points

Discussion

Implication

Cite This Study

Sequential Treatment With Corticosteroids and Cyclosporine A in a High-Risk Patient With IgG-Negative Immunotactoid Glomerulopathy

Key Points

Discussion

Implication

Cite This Study

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