What question did this study set out to answer?

To examine the relationship between lung cancer tumorigenesis and the tumor microenvironment (TME).

Tumorigenesis and Tumor Microenvironment in Lung Cancer

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Analysis of tumor microenvironment influences on lung cancer development, indicating novel therapeutic targets.

To examine the relationship between lung cancer tumorigenesis and the tumor microenvironment (TME).
Reviewed recent evidence linking TME ecology and lung tumorigenesis across different histologies.
Analyzed factors like CAF heterogeneity and immune niche organization.
Evaluated therapeutic strategies targeting or reprogramming the TME.
Highlighted the role of immune niches in tumor progression and therapy response.
Identified chronic injuries that reshape local tissue programs in lung cancer.
Discussed emerging therapies like immune checkpoint blockade targeting the TME.

Dhillon et al. (2026) studied this question.

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