This analysis explores the relationship between epilepsy and cognitive decline in Alzheimer Disease, indicating a significant overlap in impairments.
Alzheimer disease (AD) and epilepsy are major causes of neurologic disability and are reciprocally related: epileptiform discharges, subclinical seizures, and epilepsy are more prevalent in patients with AD compared with controls; progressive cognitive impairment commonly afflicts epilepsy patients; and late-onset epilepsy patients have higher rates of new-onset dementia.
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Devinsky et al. (2026) studied this question.
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