What question did this study set out to answer?

To assess whether aberrant excitatory neuronal activity acts as an upstream driver of cognitive deficits in Alzheimer disease rather than an incidental byproduct of late-stage neurodegeneration.

February 9, 2009Archives of NeurologyOpen Access

Epilepsy and Cognitive Impairments in Alzheimer Disease

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Authors

JPJorge J. PalopGladstone Institutes

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Implication

Narrative review reveals aberrant excitatory neuronal activity accelerates cognitive decline in Alzheimer disease, indicating potential therapeutic utility of antiepileptic treatments.

Key Points

To assess whether aberrant excitatory neuronal activity acts as an upstream driver of cognitive deficits in Alzheimer disease rather than an incidental byproduct of late-stage neurodegeneration.
Synthesized molecular and behavioral evidence from transgenic mouse models of Alzheimer disease with elevated beta-amyloid levels.
Reviewed human clinical and genetic data encompassing sporadic Alzheimer disease, familial early-onset pedigrees (APP, PSEN1, PSEN2 mutations), and asymptomatic APOE-ε4 carriers.
Elevated brain beta-amyloid induces epileptiform activity that directly drives cognitive impairment in transgenic mouse models.
Seizure activity in human Alzheimer disease occurs independently of disease stage, is most frequent in early-onset cases, appears subclinically in non-demented APOE-ε4 carriers, and episodic amnestic symptoms resolve with antiepileptic pharmacotherapy.

Cite This Study

Jorge J. Palop (2009) studied this question.

synapsesocial.com/papers/69dd621780eea7d3f699c5c2 https://doi.org/10.1001/archneurol.2009.15

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Implication

Narrative review reveals aberrant excitatory neuronal activity accelerates cognitive decline in Alzheimer disease, indicating potential therapeutic utility of antiepileptic treatments.

Epilepsy and Cognitive Impairments in Alzheimer Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Epilepsy and Cognitive Impairments in Alzheimer Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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