Why the study?
Does female sex increase the risk of stroke in older patients with recently diagnosed atrial fibrillation compared to male sex?
Population
83,513 patients 65 years or older admitted to the hospital with recently diagnosed atrial fibrillation in…
Comparison
Female sex vs Male sex
Design
Cohort
Key result
Among older patients with recently diagnosed atrial fibrillation, women had a higher risk of stroke than men (adjusted HR 1.14; 95% CI 1.07-1.22; P<.001), regardless of warfarin use.
Authors
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Women with new AF had higher stroke risk independent of warfarin; leaves open whether sex-specific thresholds should refine future risk scores.
Cohort (n=83,513)
Does female sex increase the risk of stroke in older patients with recently diagnosed atrial fibrillation compared to male sex?
Effect estimate: adjusted HR 1.14 (95% CI 1.07-1.22)
Absolute Event Rate: 2.02% vs 1.61%
p-value: p=<.001
Among older patients with recently diagnosed atrial fibrillation, women have a significantly higher risk of stroke than men, which is not explained by differences in warfarin utilization.
Hart et al. (2012) conducted a cohort in Atrial fibrillation (n=83,513). Female sex vs. Male sex was evaluated on Risk of stroke (adjusted HR 1.14, 95% CI 1.07-1.22, p=<.001). Among older patients with recently diagnosed atrial fibrillation, women had a higher risk of stroke than men (adjusted HR 1.14; 95% CI 1.07-1.22; P<.001), regardless of warfarin use.