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The aim was to synthesize new 2-substituted quinazolin-4(3H)-ones using S-arylation reactions.

Synthesis of Novel 2-(4-Arylthiophenyl)quinazolin-4(3H)-ones Using S-Arylation Reaction

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Research demonstrates the synthesis of new quinazolin-4(3H)-ones, suggesting potential for luminescent applications.

The aim was to synthesize new 2-substituted quinazolin-4(3H)-ones using S-arylation reactions.
Condensation of 2-aminobenzamide and 4-methylthiobenzaldehyde to form azomethine.
Isolation of azomethine followed by dehydrogenation using DDQ.
Reaction of quinazolin-4(3H)-ones with arynes generated from anthranilic acids.
The S-arylation reaction successfully produced several new 2-substituted quinazolin-4(3H)-ones.
A similar procedure yielded 4-phenyl substituted 2-arylquinazolines.
New quinazolines displayed solid-state fluorescence with absolute quantum yields up to 10%.

Kudryashova et al. (2026) studied this question.

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