What question did this study set out to answer?

The research aims to evaluate the cross-protection provided by the seasonal influenza vaccine against swine influenza A viruses.

February 28, 2026VaccinesOpen Access

Investigation of Potential Cross-Protection Conferred by the Seasonal Influenza Vaccine Against Swine Influenza A Viruses of Pandemic Potential

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Authors

ALAlice LilleyScripps Research Institute CCChiara ChiapponiIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini"APAlice Prosperi

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Implication

Investigation assesses seasonal influenza vaccine's effectiveness against swine influenza A viruses in humans, implying potential pandemic implications.

Key Points

The research aims to evaluate the cross-protection provided by the seasonal influenza vaccine against swine influenza A viruses.
Measured cross-reactive antibodies in human serum samples before and after vaccination.
Used haemagglutination and microneutralisation assays to assess antibody response.
Tested diverse swine influenza A virus clades against vaccine-induced sera from healthy adults.
Post-vaccination antibody titres showed clade-dependent boosting but often fell short of protective levels.
Significant recognition of the 1C.2.1 clade virus, contrasted by low antibody responses to the 1A.3.3.2 clade.
Indicates some utility of seasonal influenza vaccines against specific swine variant outbreaks while necessitating strain-specific vaccines.

Cite This Study

Lilley et al. (2026) studied this question.

synapsesocial.com/papers/69a287a00a974eb0d3c036e5 https://doi.org/10.3390/vaccines14030211

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Implication

Investigation assesses seasonal influenza vaccine's effectiveness against swine influenza A viruses in humans, implying potential pandemic implications.

Investigation of Potential Cross-Protection Conferred by the Seasonal Influenza Vaccine Against Swine Influenza A Viruses of Pandemic Potential

Discussion

Member takes

Implication

Key Points

Cite This Study

Investigation of Potential Cross-Protection Conferred by the Seasonal Influenza Vaccine Against Swine Influenza A Viruses of Pandemic Potential

Discussion

Member takes

Implication

Key Points

Cite This Study

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