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Research reveals that P2X7R deficiency enhances mitophagy, reducing cardiac ageing, indicating possible targets for treatment.
Our findings provide valuable insights into the role of P2X7R in cardiac ageing and identify the HuR/TRIM26/NR4A1 axis as a key signalling pathway through which P2X7R regulates cardiac ageing.
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Zhou et al. (2026) studied this question.
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