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February 20, 2026Journal of Medicine and Palliative Care

Boric acid preserves keratinocyte viability, migration, and redox homeostasis under hydrogen peroxide–induced oxidative stress in HaCaT keratinocytes

Burcu Biltekin Şeyma Dümür Naile Fevziye Mısırlıoglu Hafize Uzun

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Key Points

This study investigates the protective effects of boric acid on keratinocytes exposed to oxidative stress from hydrogen peroxide.
HaCaT keratinocytes exposed to varying concentrations of hydrogen peroxide and boric acid for 24 and 48 hours
Cell viability measured using the CCK-8 assay
Migration assessed via an in vitro scratch assay
Three-dimensional spheroid formation evaluated in a 3D culture model
High-dose boric acid significantly reduced cell viability at 24 hours
Low-dose boric acid did not affect cell viability
Hydrogen peroxide decreased cell viability in a time- and dose-dependent manner

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Implication

Aiming to uncover the effects of boric acid on wound healing, this study shows improved keratinocyte function under oxidative stress.

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Cite This Study

Biltekin et al. (2026) studied this question.

synapsesocial.com/papers/69a287f20a974eb0d3c03cf8 https://doi.org/10.47582/jompac.1861514

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A Novel Butylated Caffeic Acid Derivative Protects HaCaT Keratinocytes from Squalene Peroxidation-Induced StressOriginal Research · 2019 · 6 citations
2Protective Effect of Boric Acid Against Ochratoxin A-Induced Toxic Effects in Human Embryonal Kidney Cells (HEK293): A Study on Cytotoxic, Genotoxic, Oxidative, and Apoptotic Effects2024 · 9 citations
3Concentration-Dependent Effects of Boric Acid on Osteogenic Differentiation of Vascular Smooth Muscle Cells2024 · 4 citations
4(226) Investigation of Proliferative and Cytotoxic Effects of Low and High Doses of Boric Acid Exposure on Mouse Gc-1spg Spermatogonial CellsOriginal Research · 2026
5An Aqueous Extract of Beta vulgaris subsp. Vulgaris Beetroot Group Reduces Lipid Accumulation in Human Keratinocyte CellsOriginal Research · 2026

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Protective Effect of Retinoic acid preconditioning on H2O2-induced Apoptosis in Hair Cell-like Cells2022
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