Native Carboxylate Assisted Palladium/Norbornene Mediated Distal C-H functionalization of Ferrocene

Q: What does this research mean for the field?

The native carboxylate assisted Pd/norbornene mediated method enables highly regioselective C(3)-arylation of ferrocene carboxylic acids without the need for auxiliary ligands. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Princi Gupta; Brijesh Patel; Shivam Waske; Suchithra Madhavan; Manmohan Kapur

doi:10.1039/d6cc00066e

January 1, 2026Chemical Communications

Native Carboxylate Assisted Palladium/Norbornene Mediated Distal C-H functionalization of Ferrocene

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Key Points

To explore a ligand-enabled method for the regioselective C(3)-arylation of ferrocene carboxylic acids using palladium and norbornene.
Utilized a native carboxylate-assisted approach
Employed palladium/norbornene (NBE) as catalysts
Conducted a Catellani-type reaction for functionalization
Achieved highly regioselective C(3)-arylation of ferrocene
Demonstrated compatibility with commercially available ferrocene carboxylic acids

Implication

Demonstrates regioselective C(3)-arylation in ferrocene carboxylic acids, suggesting a new synthetic approach.

Abstract

Herein, we disclose a ligand-enabled, auxiliary-free, native carboxylate assisted Pd/norbornene(NBE) mediated highly regioselective C(3)-arylation of commercially available ferrocene carboxylic acids. This unique approach utilizes the Catellani-type reaction for the distal...

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Cite This Study

Gupta et al. (2026) studied this question.

synapsesocial.com/papers/69a287f20a974eb0d3c03d37 https://doi.org/10.1039/d6cc00066e

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Native Carboxylate Assisted Palladium/Norbornene Mediated Distal C-H functionalization of Ferrocene

Key Points

Implication

Abstract

Discussion

Cite This Study

Native Carboxylate Assisted Palladium/Norbornene Mediated Distal C-H functionalization of Ferrocene

Key Points

Implication

Abstract

Discussion

Cite This Study

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