What does this research mean for the field?

The native carboxylate assisted Pd/norbornene mediated method enables highly regioselective C(3)-arylation of ferrocene carboxylic acids without the need for auxiliary ligands. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To explore a ligand-enabled method for the regioselective C(3)-arylation of ferrocene carboxylic acids using palladium and norbornene.

February 28, 2026Chemical Communications1 citations

Native Carboxylate Assisted Palladium/Norbornene Mediated Distal C-H functionalization of Ferrocene

PGPrinci GuptaIndian Institute of Science Education and Research, Bhopal BPBrijesh PatelIndian Institute of Science Education and Research, Bhopal SWShivam WaskeIndian Institute of Science Education and Research, Bhopal

Key Points

To explore a ligand-enabled method for the regioselective C(3)-arylation of ferrocene carboxylic acids using palladium and norbornene.
Utilized a native carboxylate-assisted approach
Employed palladium/norbornene (NBE) as catalysts
Conducted a Catellani-type reaction for functionalization
Achieved highly regioselective C(3)-arylation of ferrocene
Demonstrated compatibility with commercially available ferrocene carboxylic acids

Abstract

Herein, we disclose a ligand-enabled, auxiliary-free, native carboxylate assisted Pd/norbornene(NBE) mediated highly regioselective C(3)-arylation of commercially available ferrocene carboxylic acids. This unique approach utilizes the Catellani-type reaction for the distal...

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