Key result
In oHCM, female and Black patients are linked to substantially higher stroke and heart failure rates.
Why the study?
Obstructive hypertrophic cardiomyopathy is associated with adverse clinical outcomes, but real-world clinical outcomes, health care resource use, and costs stratified by sociodemographic characteristics had not been evaluated.
Do clinical outcomes, health care resource use, and costs vary by sociodemographic characteristics in adults with obstructive hypertrophic cardiomyopathy?
Do clinical outcomes, health care resource use, and costs vary by sociodemographic characteristics in adults with obstructive hypertrophic cardiomyopathy?
In patients with obstructive hypertrophic cardiomyopathy, there are significant disparities in adverse cardiovascular events, resource utilization, and healthcare costs based on sex, race, age, and geographic region.
Warrants sociodemographic-tailored monitoring in oHCM; extends known CV outcome disparities to this population.
Background Obstructive hypertrophic cardiomyopathy (oHCM) is associated with adverse clinical outcomes. This study aimed to evaluate real‐world clinical outcomes, health care resource use, and health care costs in patients with oHCM stratified by their sociodemographic characteristics. Methods This retrospective, noninterventional cohort study from the Optum Market Clarity Integrated Clinical and Claims database included US adults with ≥2 medical claims with a diagnosis code for oHCM (2013–2021). Dependent on outcome measure, follow‐up was variable, fixed 1‐year, or fixed 5‐year. Outcome measures were rate of major adverse cardiovascular events, medication use, HCRU, and health care costs. Results The study included 14 744 patients with oHCM (mean±SD age, 61.8 [14.0] years; 7504 [50.9%] female). Female patients had a higher rate of stroke than male patients (6863 versus 4773 per 100 000 patient‐years), and Black patients had a higher rate of heart failure than White patients (31 084 versus 20 603). Patients in the South had a higher rate of heart failure than patients in the Northeast (25 406 versus 18 705). Patients aged 18 to 39 years had more mean±SD HCM‐related ambulatory visits per patient per month (0.41 [0.48]) than older patients (eg, aged 75+, 0.27 [0.35]). Patients in the Midwest had the greatest mean±SD HCM‐related health care costs per month (2071 [6420] USD) versus patients in other regions (eg, Northeast 1440 [3912] USD). Differences between groups were significant ( P <0.001). Conclusions In patients with oHCM, rate of major adverse cardiovascular events, health care resource use, and health care costs varied substantially between sociodemographic groups. Further studies are required to understand the causes of the observed variation between sociodemographic groups.
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Reza et al. (2026) studied this question. In obstructive hypertrophic cardiomyopathy, female patients had stroke rates of 6863 vs 4773, Black patients had heart failure rates of 31,084 vs 20,603 per 100,000 PY vs White patients.
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