3D ECM-Inflammation Model on a Microfluidic Chip for Neutrophil Transmigration from Whole Blood Investigations

Q: What does this research mean for the field?

A 3D ECM-inflammation model on a microfluidic chip enables the investigation of neutrophil transmigration from whole blood. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Shide Bakhtiari; Vanessa Velasco; Ronald W. Davis

doi:10.1039/d5lc00554j

January 1, 2026Lab on a Chip

3D ECM-Inflammation Model on a Microfluidic Chip for Neutrophil Transmigration from Whole Blood Investigations

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Key Points

The aim is to examine how neutrophils behave during inflammation in a controlled environment using a microfluidic chip.
Developed a 3D ECM inflammation model on a microfluidic chip.
Utilized whole blood to study neutrophil behavior.
Monitored neutrophil transmigration in response to inflammation.
Demonstrated effective neutrophil transmigration across the chip.
Highlighted key cellular responses relevant to inflammation.
Provided insights into the dynamics of neutrophil behavior in inflammatory conditions.

Implication

In vitro model investigates neutrophil transmigration in inflammation, suggesting improved understanding of disease mechanisms.

Abstract

Neutrophils have been linked to several inflammation diseases. To study the role of neutrophils in inflammation diseases and conditions, in vitro inflammation assays have been developed. Two drawbacks of these...

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Cite This Study

Bakhtiari et al. (2026) studied this question.

synapsesocial.com/papers/69a287f20a974eb0d3c03d7a https://doi.org/10.1039/d5lc00554j

View Full Paper

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3D ECM-Inflammation Model on a Microfluidic Chip for Neutrophil Transmigration from Whole Blood Investigations

Key Points

Implication

Abstract

Discussion

Cite This Study

3D ECM-Inflammation Model on a Microfluidic Chip for Neutrophil Transmigration from Whole Blood Investigations

Key Points

Implication

Abstract

Discussion

Cite This Study

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