Comparative Transcriptomic Analysis Reveals Divergent Host Cell Responses to Classical and Variant Pseudorabies Virus Strains

Key Points

• The aim is to compare host cell responses to different strains of pseudorabies virus to understand their effects.
• Conducted transcriptomic analysis on host cells infected with classical and variant PRV strains.
• Analyzed gene expression profiles to identify differences in cellular responses.
• Utilized data from various bioinformatics tools for comparative analysis.
• Identified distinct gene expression patterns between classical and variant PRV strain infections.
• Notable differences in immune response genes were found depending on the viral strain.
• Results suggest that variant strains may have evolved mechanisms to evade host defenses.