What question did this study set out to answer?

This review aims to outline the pathogenesis and signaling pathways in polycystic ovarian syndrome (PCOS) and discuss recent studies on therapeutic approaches.

February 28, 2026Current Pharmaceutical Biotechnology

Polycystic Ovarian Syndrome (PCOS): A Brief Overview on Pathogenesis, Main Signaling Pathways, and Recent Studies Performed on Letrozoleinduced PCOS in Rodents

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Authors

HAHana AbduljabbarKing Abdulaziz University MJMaha JamalKing Abdulaziz University AEAhmed EsmatAin Shams University

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Implication

This review summarizes the molecular pathways and treatment effects observed in letrozole-induced PCOS models, highlighting potential therapies.

Key Points

This review aims to outline the pathogenesis and signaling pathways in polycystic ovarian syndrome (PCOS) and discuss recent studies on therapeutic approaches.
Reviewed studies from PubMed and Web of Science databases on PCOS and letrozole-induced PCOS in rodents
Examined contributions of various factors like hyperandrogenism and insulin resistance to PCOS pathogenesis
Summarized therapeutic approaches tested in rodent models over the past five years
Identified key signaling pathways in PCOS including PI3KAKT, MAPK, NF-κB, and Keap-1-Nrf2
Documented therapeutic effects of resveratrol, probiotics, and lifestyle modifications on PCOS management
Showed promising outcomes for various therapies that could inform future PCOS treatment plans

Cite This Study

Abduljabbar et al. (2026) studied this question.

synapsesocial.com/papers/69a288590a974eb0d3c043b9 https://doi.org/10.2174/0113892010433981251031050335

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Implication

This review summarizes the molecular pathways and treatment effects observed in letrozole-induced PCOS models, highlighting potential therapies.

Polycystic Ovarian Syndrome (PCOS): A Brief Overview on Pathogenesis, Main Signaling Pathways, and Recent Studies Performed on Letrozoleinduced PCOS in Rodents

Discussion

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Implication

Key Points

Cite This Study

Polycystic Ovarian Syndrome (PCOS): A Brief Overview on Pathogenesis, Main Signaling Pathways, and Recent Studies Performed on Letrozoleinduced PCOS in Rodents

Discussion

Member takes

Implication

Key Points

Cite This Study

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